• Lemme, the supplement brand founded by Kourtney Kardashian Barker, is releasing an “all-natural” weight loss supplement called Lemme GLP-1 Daily.
• In spite of the name, the product is not a GLP-1 receptor agonist like Ozempic or Wegovy.
• The product contains natural ingredients such as Eriomin lemon fruit extract, Supresa saffron extract and Morosil red orange fruit extract.

Lemme, the supplement brand founded by Kourtney Kardashian Barker, announced that it is releasing a supplement called Lemme GLP-1 Daily aimed at providing consumers with an “all-natural” way to manage their weight.

In spite of its name, however, the product does not contain a synthetic GLP-1 hormone and is not a GLP-1 receptor agonist like Ozempic or Wegovy.

Ozempic and other GLP-1 drugs mimic the actions of the hormone GLP-1 by activating its receptor, which leads to weight loss and lower blood sugar, among other benefits.

Lemme GLP-1 Daily instead contains natural ingredients such as Eriomin lemon fruit extract, Supresa saffron extract and Morosil red orange fruit extract.

The product is meant to “boost the body’s GLP-1 levels, reduce hunger, promote insulin sensitivity and support healthy weight management,” according to a company press release.

The daily capsules will be available for purchase on the brand’s website beginning September 16 and will be sold via a subscription model at $72 for a month’s supply or $90 as a one-time purchase.

But how effective is the product for weight loss? Here’s what to know about the potential benefits of the natural ingredients in Lemme GLP-1 Daily.

Lemon fruit extract

Small clinical trials of Eriomin lemon fruit extract found that this compound didn’t help people lose weight, but it may offer other benefits.

A small study of people with prediabetes and type 2 diabetes who took Eriomin for 12 weeks showed that there was no effect on body weight, body mass index (BMI), lean mass, fat mass or waist-to-hip ratio.

However, those who took Eriomin saw on average a 5% decrease in their blood glucose and a 17% increase in the hormone GLP-1, compared to those who took a non-acting placebo.

Another small 12-week study of people with prediabetes also found that Eriomin had no impact on weight. But there was a 22% increase in blood levels of GLP-1, and an increase in beneficial bacteria in the gut.

Bacteria in the gut can influence your weight by affecting how food is digested, how fat is stored, and whether you feel full or hungry.

Eating a wide variety of high fiber foods such as whole grains, fruits, vegetables, nuts, and seeds — and limiting intake of added sugars and highly processed foods — can also support healthy gut bacteria.

Saffron extract

An 8-week study of 60 women with overweight found that those who took a saffron extract had decreased snacking, compared to those who took a placebo.

GLP-1 drugs work, in part, by reducing appetite and feelings of hunger, which can help people manage their weight.

However, studies of saffron extract have not shown a large effect on weight when the compound is used alone.

A meta-analysis of 25 earlier studies looking at the benefits of saffron extract found that people with obesity who took this compound saw decreases in their waist-to-hip ratio.

There were also decreases in weight, BMI, waist circumference, and hip circumference. However, these changes were not statistically significant, which means saffron extract may not offer any additional benefits compared to a placebo.

Two other studies, including a review paper of previous studies and a small clinical trial in people with type 2 diabetes, also found that saffron extract didn’t help people lose weight.

Other studies have examined the benefits of saffron extract for people with diabetes, such as improving blood glucose control and cholesterol levels. Some of these studies were done alongside other supplements like cinnamon and ginger or in conjunction with aerobic or resistance exercise.

Red orange fruit extract

The clearest weight loss benefits are seen with Morosil red orange fruit extract.

A six-month study found that people who were living with overweight lost an average of 4.2% of their body weight while taking Morosil, compared to 2.2% in people who took a placebo. The Morosil group also saw larger decreases in hip and waist circumference, fat mass, and fat distribution.

In contrast, one study found that people who took semaglutide — the active ingredient in Ozempic and Wegovy — lost 15.8% of their body weight over 68 weeks.

Learn more about how to get GLP-1 medications like Ozempic and Wegovy from vetted and trusted online sources here:

• How to Get Ozempic: Everything You Need to Know
• Where to Buy Ozempic Online
• How to Get Wegovy for Weight Loss In Person and Online
• How to Get a Wegovy Prescription Online
• How to Get Zepbound: What We Know So Far
• Where to Buy Zepbound Online
• How to Get Mounjaro (Tirzepatide)
• Where to Buy Mounjaro (Tirzepatide) Online

Are supplements useful for weight loss?

Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, Calif., has concerns about how supplements used for weight loss are sometimes promoted.

“GLP-1 medications stimulate hormones in the body and have the same effect as those hormones. So when people claim supplements do the same thing, I think that’s a bit deceptive,” he told Healthline.

And while “for some people, a natural, herbal supplement can be effective, there’s no convincing evidence that the supplement is going to have a significant effect on weight loss.”

Libu Varughese, MBBS, an endocrinology physician and medical advisor of Aeroflow Diabetes, told Healthline that he would like to see more scientific evidence before recommending the use of natural GLP-1 supplements.

However, if you do choose to use a dietary supplement, do so with caution, he said, and watch for any negative side effects.

The Food and Drug Administration has information for consumers on safely using dietary supplements.

Amy Lee, MD, head of nutrition for Nucific, suggests that people who want to lose weight naturally, think of supplements as just one component of a weight management program.

People also need to make “behavioral changes that result in decreased caloric intake and increased energy expenditure through movement and exercise,” she told Healthline.

Ali said certain diets have been shown in clinical trials to support weight loss, including ones that involve eating fewer carbohydrates, such as the keto diet and paleo diet.

“These diets are based on minimizing carbohydrate intake to direct the body toward burning fat,” Ali said. “That’s natural. There are no medications involved. No supplements. It’s just eating the right things to promote the burning of fat.”

These kinds of diets are even helpful for people who have had bariatric surgery or are taking a GLP-1 medication, he said, “because if you’re not eating the right things, you won’t see as much results.”

Takeaway

Lemme, the supplement brand founded by Kourtney Kardashian Barker, is releasing a supplement called Lemme GLP-1 Daily to provide consumers with an “all-natural” way to manage their weight.

In spite of its name, the product does not contain a synthetic GLP-1 hormone, and it is not a GLP-1 receptor agonist like Ozempic or Wegovy.

GLP-1 drugs mimic the actions of the GLP-1 hormone to lower blood glucose and promote weight loss.

Lemme GLP-1 Daily contains natural ingredients such as Eriomin lemon fruit extract, Supresa saffron extract and Morosil red orange fruit extract. Clinical studies show that these compounds may promote modest weight loss, decrease hunger and appetite, or boost the body’s GLP-1 levels.